Continuous, On-Demand Dehydration of Solvents in Flow Chemistry Manufacturing Processes | CPhI North America

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Continuous, On-Demand Dehydration of Solvents in Flow Chemistry Manufacturing Processes

Hannah Murnen (PhD., Chief Technical Officer, Compact Membrane Systems)

Location: E353b

Date: Wednesday, May 1

Time: 2:15pm - 3:00pm

Track: Drug Development

Vault Recording: TBD

Anhydrous solvents can be critical in the development and production of new pharmaceutical molecules, affecting yield, product quality and process efficiency to name just a few key elements. Production and management of those anhydrous solvents is not always trivial given the temperature, quality and process requirements of APIs, particularly in flow chemistry systems. Membrane dehydration and purification can provide an avenue for efficient and cost-effective, on-demand production of these anhydrous solvents. Compact Membrane Systems has installed several fluoropolymer membrane pervaporation systems into flow chemistry manufacturing processes to allow inline dehydration of solvents. One example of this work was published in OPR&D along with authors from Pfizer and Asymchem and provides a new route to manage solvents in flow chemistry processes. This session will discuss solvent purification and management in flow chemistry processes using pervaporation membranes and would also cover specific operational issues such as how to manage low flow rates or small hold up volumes.

Key takeaways Attendees to this session will learn:

1) Anhydrous solvents can be very important in drug development, particularly in flow chemistry reactions and can be difficult to scale up from a lab process.
2) An overview of membrane pervaporation and the fundamental characteristics that govern the performance of membrane pervaporation.
3) How fluoropolymer membrane pervaporation systems can be used to product anhydrous solvents continuously.
4) These fluoropolymer based systems are compatible with most solvents and operating conditions, giving them broad applicability in drug development manufacturing.

Presentation File