View, browse and sort the list of CPhI North America Conference sessions and show floor programming by pass type, track, and format. Seating is first come, first serve, so please arrive early to sessions that you would like to attend. Sessions are subject to change.

Toxicology Strategies for Drug Discovery: Personal Thoughts


Eric Blomme (Vice President Global Preclinical Safety, AbbVie)

Location: 119A

Date: Wednesday, April 25

Time: 11:30am - 12:15pm

Pass Type: Conference Pass, VIP Attendee - Get your pass now!

Track: Drug Development

Vault Recording: TBD

American Chemical Society (ACS)
Powered By

  • Impact of nonclinical safety-related attrition on pharmaceutical R&D productivity
    • When is the impact most significant and for what type of molecules?
    • What is an achievable, realistic nonclinical safety-related attrition rate?
    • How to achieve it?
  • Front-loading toxicity testing
    • What are the challenges?
    • Why is ADMET profiling working and not Tox profiling?
    • Where is it useful?
  • Physicochemical Properties: Addressing the challenge of “molecular obesity”
    • 3/75 rule and toxicity
    • A guide, but not a cause for termination
  • In Vitro and computational toxicology tools
    • High-throughput cytotoxicity assays
    • Molecular profiling
    • Computational approach to identify off-target interactions