Connect Conference & Show Floor Educational Sessions

View, browse and sort the list of Connect Conference sessions and show floor programming by pass type, track, and format. Please note, all Connect Conference delegates have access to CPhI Connect and InformEx Connect programming. Seating is first come, first serve, so please arrive early to sessions that you would like to attend. Sessions are subject to change.

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  • Formulation Trends for Topical Dosage Forms

    Speakers:
    • Amy Ethier  |  PhD, Formulation Scientist, Skin Delivery, BASF Pharma Solutions
    • Norman Richardson  |  Global Technical Development and Marketing Manager, Skin Delivery, BASF Pharma Solutions
    Location:  113A
    Track: Drug Development
    Pass Type: Connect Delegate, VIP Attendee - Get your pass now!
    Vault Recording: TBD

    In topical drug formulations the selection of excipients, the amount of each excipient and the complexes and phases that they form in the formulation are collectively responsible for all of the performance attributes of the final product. By their physicochemical nature different classes of topical excipients (e.g. high melting point lipidic materials, oils, hydrophilic fluids, linear and globular polymers, nonionic and anionic and cationic emulsifiers, etc.) perform different functions in the topical dosage form.

    Excipients contribute to or influence viscosity, spreadability, aesthetic properties, API solubilization and/or solid state, as well as the physical and chemical stability of the formulation, dermal drug permeation and many other attributes. Formulators seek to leverage excipient functionalities to develop products with specific performance attributes that (1) allow for aesthetically acceptable application to the treatment area, (2) deliver the active to the appropriate location (e.g. surface of the skin, epidermis, dermis, systemic, etc.), (3) enable the active to permeate the stratum corneum barrier, when necessary, (4) prevent irritation and maintain mildness throughout the use of the product and (5) maintain chemical and physical stability of the product throughout its shelf life.

    To achieve these objectives a variety of dosage forms are available to the topical drug formulator (e.g. emulsions, gels, ointments, foams, solid sticks and balms, sprays, patches, etc.). How excipients are chosen to achieve various dosage forms will be discussed. A hands-on, interactive session will explore the different dosage forms that are available in the market place. Some examples from the BASF Global Skin Delivery Lab will also be available for evaluation.

    Learn how and why to select a specific dosage form including:

    I. What are the design criteria for your topical formulation
    • Ease of application
    • Good sensory properties
    • Drug delivery options
    - Retain on surface of skin
    - Deposit into epidermis, scalp, nail or mucosal membrane
    - Penetrate skin for systemic delivery
    - Controlled release
    • Mildness, impurities and support of healing of compromised skin
    • API solubility, stability and compatibility and dosage strength

    II. What dosage forms are available and which one should you use?
    • Emulsions (biphasic creams and lotions)
    • Gels (single phase aqueous semi-solid)
    • Foams (aerosol and non-aerosol, aqueous and anhydrous)
    • Ointments (hydrophobic and hydrophilic)
    • Solid sticks and balms (hydrophobic and hydrophilic)
    • Film forming topicals
    • Sprays
    • Patches

    III. Interactive Session
    Participants will observe, touch, feel and evaluate the application and performance of products from the market place and placebo dosage forms from the lab. In some cases systematic sensory evaluations may be employed.