View, browse and sort the list of CPhI North America Conference sessions and show floor programming by pass type, track, and format. Seating is first come, first serve, so please arrive early to sessions that you would like to attend. Sessions are subject to change.

Technology and Formulation Selection for Bioavailability Enhancement

Speaker:

Michael Grass (Principal Scientist, Lonza)

Location: 119A

Date: Wednesday, April 25

Time: 10:15am - 11:00am

Pass Type: Conference Pass, VIP Attendee - Get your pass now!

Track: Drug Development

Vault Recording: TBD

American Chemical Society (ACS)
Powered By

  • Problem Statement Definition
    • Potential barriers to absorption and low bioavailability
    • How compound properties, dose/PK expectation and physiology come into play
    • Model based approach
  • Technology Selection
    • Overview of technology options
    • Mating problem statement with technology
    • Philosophy for ‘Right First Time’ using performance, manufacturability and stability approach
    • In Vitro tools
  • Innovations in Formulation and Processing
    • Multi-component SDDs
    • High SDD loaded Dosage Forms
    • Processing ‘Brickdust’ Compounds
  • Spray Dried Dispersion Development (Case Study)
    • Using a model system to demonstrate how the approach and tools described above are used to select the most optimal formulation.