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Technology and Formulation Selection for Bioavailability Enhancement


Michael Grass (Principal Scientist, Lonza)

Location: 119A

Date: Wednesday, April 25

Time: 10:15am - 11:00am

Pass Type: Conference Pass, VIP Attendee - Get your pass now!

Track: Drug Development

Vault Recording: TBD

American Chemical Society (ACS)
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  • Problem Statement Definition
    • Potential barriers to absorption and low bioavailability
    • How compound properties, dose/PK expectation and physiology come into play
    • Model based approach
  • Technology Selection
    • Overview of technology options
    • Mating problem statement with technology
    • Philosophy for ‘Right First Time’ using performance, manufacturability and stability approach
    • In Vitro tools
  • Innovations in Formulation and Processing
    • Multi-component SDDs
    • High SDD loaded Dosage Forms
    • Processing ‘Brickdust’ Compounds
  • Spray Dried Dispersion Development (Case Study)
    • Using a model system to demonstrate how the approach and tools described above are used to select the most optimal formulation.

Presentation File